It was a stronger and more stable response in comparison to IgG. their individual immune status had a number of features. Approximately 39.22% (20 of 51 PTPRC people) of project participants diagnosed with COVID19 showed an unusual change in plasma antiSARSCoV2 IgA levels. Relatively high levels of IgA (ratio ~ 3) after recovery persisted for a long time (more than 6 months). In onethird (17 of 51 people) of patients with COVID19, the IgA level exceeded the IgG level. IgA antibodies appeared earlier and showed a stronger and more robust response to the SARSCoV2 computer virus than IgG. Increased levels of antiSARSCoV2 IgA (ratio from 0.8 to GAP-134 Hydrochloride 2.36) throughout the observation period were recorded in 28 of 180 project participants (15.56%) of whom only one person fell ill with COVID19. Keywords:antiSARSCoV2 immunoglobulins, COVID19, humoral immunity, longterm monitoring == Highlights == For SARSCoV2 coronavirus unlike other viruses IgA remains in the blood for a long time. In some patients who recovered from COVID19 the IgA immune response was stronger and more stable than IgG. Some healthy people have elevated blood levels of IgA to SARSCoV2. == 1. INTRODUCTION == The global pandemic of the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARSCoV2) in 2020 has challenged the entire global medical community. SARSCoV2 has shown extreme prevalence due to its extremely high contagiousness and the long incubation period before symptoms of coronavirus disease 2019 (COVID19) appear. It is difficult to control asymptomatic carriers of the computer virus, newly infected individuals during the incubation period, and clinically recovered patients who are still infected with the computer virus. An additional problem in the fight against infection is the wide range of COVID19 clinical manifestations from asymptomatic carriage to severe acute respiratory distress syndrome leading to severe complications and deaths.1Despite significant advances in the scientific description of the coronaviruses biology,2,3the development of antiviral vaccines and the creation of effective diagnostic test systems based on polymerase chain reaction (PCR),4enzymelinked immunosorbent assay (ELISA),5and chemiluminescence immunoassay,6a number of aspects of the COVID19 development remain unclear. The study of the nature, severity, and duration of the human immune response after contact with the SARSCoV2 coronavirus and the assessment of the antibodies prevalence in the population will make it possible to predict the epidemiological situation development in distinct countries more accurately and to plan measures to prevent the infection. Today, it is obvious that this immune response to SARSCoV2 contamination includes all elements of the humoral immunity system and the cellular immunity system.3,7,8,9Neutralizing antibodies play a protective role in limiting infection and preventing reinfection in the future.9Specific antibody monitoring is useful both for confirming SARSCoV2 infection in PCRpositive COVID19 patients, which is important for infected but asymptomatic subjects and for patients with COVID19 who are screened several weeks after onset. Serological assessments are necessary to check the sensitivity or resistance to reinfection as well as for epidemiological studies and the implementation of control and surveillance activities because antiSARSCoV2 IgM, IgA, and IgG levels are important indicators for assessing herd populace immunity against SARSCoV2.3,10In this regard, longterm monitoring of the specific antiviral immunoglobulins levels is of undoubted interest both from GAP-134 Hydrochloride a scientific and a practical point of view. Unfortunately, most of the immunological studies are associated with severe cases of viral disease caused by the new coronavirus. So far, there are very few publications devoted to longterm monitoring of the immunological status of patients who have undergone COVID19 and people with a low viral load of SARSCoV2.11,12Today, there is absolutely no clear response to the query of whether an defense response to SARSCoV2 is formed in individuals who have been forced to exist for a long period in the surroundings of COVID19 disease, and GAP-134 Hydrochloride exactly how long the protective pool of antibodies is maintained following the disease ends. Today’s study is targeted at filling up the distance in understanding of the GAP-134 Hydrochloride consequences of the brand new coronavirus on the body with regards to humoral immunity. The goals of our task included a longterm evaluation from the advancement dynamics from the immune system response to SARSCoV2 disease through a quantitative evaluation of IgA and IgG amounts in the bloodstream of healthful donors surviving in the framework from the coronavirus pandemic and individuals who got undergone COVID19. == 2. Components AND Strategies == == 2.1. Research participants == The analysis included 180 people: 84 males and 96 ladies. Age the project individuals: ladies from 22 to 53 years of age (average.