Individual values. 3.2. (17C29 and 30C39 years of age). There were no variations between male and female individuals in levels of anti-measles antibodies or in the proportion of seronegative individuals. Analyses of antibody levels with regard to type of disease exposed the highest rate of seronegative results in cystic fibrosis individuals (34.4%, 11/32). Overall, 19% of lung transplant candidates, mostly young people and cystic fibrosis individuals, did not possess protecting immunity against measles. Keywords: measles, anti-measles immunity, lung transplant 1. Intro The prevention of vaccine-controlled infectious diseases is an important part of the management plan for individuals with progressive disorders affecting numerous organs. This is of particular importance in those instances when organ transplantation is planned due to the failure of other treatments. For recipients of solid organs, who receive life-long immunosuppressive therapy, many infections are one of the leading causes of death. Thus, this is a specific group of individuals who require, both before and after organ transplantation, thorough testing for protecting immunity against preventable infections [1,2,3,4,5,6]. Individuals with bronchopulmonary disorders are at high risk of infection-related complications. Unlike additional solid Potassium oxonate organs, the lungs are in contact with the external environment and are constantly exposed to numerous factors, including pathogens. In lung transplant candidates, infections lead to the exacerbation and progression of the underlying disease process, increasing the risk of death prior to transplant. Moreover, some features of innate and adaptive immunity in those individuals account for the poor removal of microorganisms from your respiratory tract [7]. The following factors predispose to post-transplant infections: impaired mucociliary clearance, denervation of the allograft, and the suppression of cough reflex [8]. In the post-transplant period, lung transplant recipients are at higher risk of infection-related complications than recipients of additional organs because they receive a more aggressive immunosuppressive therapy. Unique attention should be given to infections for which live attenuated vaccines are needed for prevention. Such vaccines are not recommended after the transplantation of solid organs, meaning that individuals should undergo vaccination before transplantation. Measles is definitely one of these infections. Despite active preventive measures, different countries ROCK2 have periodically confronted outbreaks of this disease over the last decade. According to the World Health Business (WHO), over 900 measles instances were reported by the end of February 2023, exceeding the number reported for all of 2022, with the Russian Federation becoming among the three countries that have reported the largest numbers Potassium oxonate of Potassium oxonate instances over the past 12 months. The COVID-19 pandemic offers obviously contributed to an increase in measles incidence, since in many countries previously scheduled immunization campaigns were either disrupted or significantly delayed [9]. Measles computer virus is a potent immunosuppressive agent, and the disease is associated with a temporary but serious immunosuppression persisting over a period of several weeks to weeks. The wild-type measles computer virus infects immune cells after binding to the cellular receptor CD150, which is definitely expressed by numerous populations of Potassium oxonate immune cells [10,11]. The infection and depletion of memory space lymphocytes results in a loss of acquired immunological memory space (immune amnesia), leading to a reduction in the levels of protecting antibodies against additional pathogens. M.J. Mina et al. reported that after severe or slight measles, children lost a median of 40% (range: 11 to 62%) or 33% (range: 12 to 73%), respectively, of their total preexisting pathogen-specific antibody repertoires. However, illness with the measles computer virus results in life-long immunity against measles itself. These data suggest that after contracting measles illness, people could shed their immunity to previously experienced pathogens against which they have developed natural defense, as well as to those against which they have been vaccinated. Later in life, immunological memory space to.