According to our results, the levels of abovementioned six inflammatory factors were higher in patients with CVT compared with those in the controls. Results The following results were obtained: (1) Inflammatory factor levels in patients with CVT were higher than those in the controls. (2) TNFRSF8 Inflammatory factor levels in the acute and subacute stages were significantly higher than those in the chronic stage (all test or MannCWhitney test was used for continuous data, while value P?=?0.049) were associated with high risk of poor outcome in the univariable model. However, the multivariate logistics analysis found no significant relationship (all P?>?0.05). Moreover, the levels of these inflammatory factors were not correlated with the prognosis of non-inflammatory CVT including the development of IH and papilledema (all P?>?0.05). Discussion It is well known that inflammation plays vital functions in artery stroke, which not only participates in the development of stroke but also plays a continuing role during the various stages of stroke and influences the outcome [26C29]. Similarly, inflammation could act as the cause of CVT, which has been exhibited by numerous previous studies [8]. However, whether the inflammation develops after CVT and is associated with its severity and outcome is not yet presently defined. As clinically easily available inflammatory biomarkers, Hs-CRP, IL-6, and NLR in the peripheral blood and Ig (A, M, G), Engeletin in the CSF were used in our study to represent the inflammatory response. According to our results, the levels of abovementioned six inflammatory factors were higher in patients with CVT compared with those in the controls. Furthermore, these inflammatory factors including Hs-CRP, IL-6, and NLR in the peripheral blood and IgA, IgM, and IgG in the CSF increased significantly during Engeletin the acute and subacute stages and decreased during the chronic stage. It indicated that inflammation may develop soon after CVT and gradually decrease Engeletin during the course. In other words, the degree of inflammation may change with the course of the disease. As in DVT, the IL-6 and CRP levels were higher on admission and then gradually declined during the subsequent days [30]. Moreover, the serum NLR and CSF IgM level were positively correlated with baseline degree of disability on admission. The Hs-CRP level was positively correlated with the development of seizure at baseline. The baseline serum NLR and CSF IgA, CSF IgM, and CSF IgG levels were positively associated with NIHSS. Although the multivariate logistics analysis found no relationship between inflammatory factors and cerebral venous infarction at baseline, the univariate logistics analysis revealed the correlation between cerebral venous infarction at baseline and serum Hs-CRP, CSF IgM, and CSF IgG levels. Hence, it is suggested that a significant correlation between inflammation and severity of CVT may exist. Previous studies have also found the correlation between Hs-CRP level and disability and.